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Truong Phuong Phan Alex Truong Buu Suen Benjamin Melles Gerrit Talke Frank 《Microsystem Technologies》2020,26(11):3403-3407
Microsystem Technologies - A low-cost, self-imaging smartphone attachment has been developed for remote slit lamp examination of the human eye. The device is designed with off-the-shelf optical... 相似文献
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Jacobson Nathan S. Kuczmarski Maria A. Kowalski Benjamin A. 《Oxidation of Metals》2020,93(3-4):247-282
Oxidation of Metals - Vaporization often accompanies high-temperature oxidation and corrosion. In this review, vaporization under a vacuum as well as static gas and flowing gas conditions is... 相似文献
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Schuessler Benjamin J. Field David P. Overman Nicole R. Joshi Vineet V. 《Metallurgical and Materials Transactions A》2021,52(9):3871-3879
Metallurgical and Materials Transactions A - Uranium alloyed with 10 wt pct Mo (U-10Mo) undergoes discontinuous precipitation (DP) when subjected to sub-eutectoid heat treatment. It is hypothesized... 相似文献
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Benjamin Diethelm-Varela 《ChemMedChem》2021,16(5):725-742
Against the challenge of providing personalized cancer care, the development of targeted therapies stands as a promising approach. The discovery of these agents can benefit from fragment-based drug discovery (FBDD) methods that help guide ligand design and provide key structural information on the targets of interest. In particular, nuclear magnetic resonance spectroscopy is a promising biophysical tool in fragment discovery due to its detection capabilities and versatility. This review provides an overview of FBDD, describes the basis of NMR-based fragment screening, summarizes some exciting technical advances reported over the past decades, and closes with a discussion of selected case studies where this technique has been used as part of drug discovery campaigns to produce lead compounds towards the design of anti-cancer targeted therapies. 相似文献
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Touching contaminated surfaces might lead to the spread of pathogens, that is, the fomite transmission route. Although hand- and surface-hygiene practices are potentially important non-pharmaceutical interventions for the fomite route, the two interventions have been mostly studied separately in the literature. In this study, we develop a new conceptual model based on the law of mass action, analyze the temporal diffusion of contaminated surfaces and hands, and verify the model with simulations in an assumed norovirus outbreak in a buffet restaurant. A quantitative hygiene criterion is developed for the required frequency of surface disinfection and hand hygiene to control the fomite transmission in indoor environments. To eliminate surface contaminations, the product of pathogen-removal rates (including hygiene and natural death) on hands and surfaces must be no smaller than that of the human hand and surface contact frequency (ie, the net removal product must be non-negative). When the net removal product is negative, the number of contaminated surfaces and hands would show a logistic growth trend and finally approach the equilibrium. Our approach sheds light into how to optimize the combined use of hand hygiene and environmental decontamination for the best effectiveness under different settings. 相似文献
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Benjamin C. Gruenwald Tansel Yucelen Animesh Chakravarthy 《International Journal of Adaptive Control and Signal Processing》2020,34(4):484-502
This article studies control and performance enforcement for a class of uncertain dynamical systems that consist of actuated and unactuated portions physically interconnected to each other. The proposed approach stabilizes the overall interconnected system in the presence of unknown physical interconnections as well as system uncertainties. Performance guarantees are enforced, individually, on the actuated as well as unactuated portions of the interconnected system via this approach. For enforcing these performance guarantees, a set-theoretic model reference adaptive control approach is used, in conjunction with linear matrix inequalities, to restrict the respective system error trajectories of the actuated and unactuated dynamics inside a priori, user-defined compact sets. The efficacy of the proposed approach is demonstrated using simulations. 相似文献
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